83207-58-3

        • Product Name:Astragaloside A
        • Molecular Formula:C41H68O14
        • Molecular Weight:784.983
        • Appearance:white powder
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        Product Details

        pd_meltingpoint:284-286oC

        Appearance:white powder

        Purity:99%

        Trustworthy Factory Supply Astragaloside A, Factory Sells 83207-58-3 with Lowest Price

        • Molecular Formula:C41H68O14
        • Molecular Weight:784.983
        • Appearance/Colour:white powder 
        • Vapor Pressure:0mmHg at 25°C 
        • Melting Point:284-286oC 
        • Refractive Index:1.62 
        • Boiling Point:895.666 °C at 760 mmHg 
        • PKA:12.91±0.70(Predicted) 
        • Flash Point:495.481 °C 
        • PSA:228.22000 
        • Density:1.395 g/cm3 
        • LogP:0.72410 

        Astragaloside A(Cas 83207-58-3) Usage

        Description

        Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.

        Uses

        Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes from apoptosis resulting from ischemia/reperfusion and inhibits inflammation signaled through TNF-α. Furthermore, astragaloside A stimulates angiogenesis, promotes the differentiation of neural stem cells, and increases neuroregeneration.

        Health effects

        As the main active ingredient of the Chinese medicine Astragalus membranaceus, Astragaloside A has a good regulatory effect on the heart. It can protect against ischemic and hypoxic cardiomyocytes, protect the heart structure, and enhance heart function.

        Pharmaceutical Applications

        Astrageloside A has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, Astragaloside A possesses potential for broad application in many diseases.

        InChI:InChI=1/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27?,28-,29+,30?,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1

        83207-58-3 Relevant articles

        TRITERPENE GLYCOSIDES OF Astragalus AND THEIR GENINS. XV. CYCLOSIVERSIOSIDES B AND D FROM Astragalus basineri

        Umarova, R. U.,Svechnikova, A. N.,Abdullaev, N. D.,Gorovich, M. B.,Abubakirov, N. K.

        , p. 174 - 177 (1984)

        Two new glycosides have been isolated fr...

        Functional Characterization and Protein Engineering of a Triterpene 3-/6-/2′-O-Glycosyltransferase Reveal a Conserved Residue Critical for the Regiospecificity

        Bao, Yang-Oujie,Gao, Bai-Han,Li, Fu-Dong,Qiao, Xue,Shi, Xiao-Meng,Su, Hui-Fei,Wang, Hai-Dong,Ye, Min,Yi, Yang,Zhang, Meng

        supporting information, (2022/01/06)

        Engineering the function of triterpene g...

        Synthetic Access Toward Cycloastragenol Glycosides

        Liu, Ting,Liao, Jin-Xi,Hu, Yang,Tu, Yuan-Hong,Sun, Jian-Song

        , p. 4170 - 4178 (2017/04/27)

        The first efficient synthetic approach t...

        Triterpene glycosides from Tragacantha stipulosa and their genins. Structure of cyclostipuloside E

        Kaipnazarov,Uteniyazov,Saatov

        , p. 40 - 44 (2007/10/03)

        The known compound trojanoside A(1) and ...

        83207-58-3 Process route

        3-O-(2,3,4-tri-O-benzoyl-β-D-xylopyranosyl)-6-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-16,25-di-O-acetylcycloastragenol

        3-O-(2,3,4-tri-O-benzoyl-β-D-xylopyranosyl)-6-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-16,25-di-O-acetylcycloastragenol

        astragaloside IV
        83207-58-3,84687-43-4

        astragaloside IV

        Conditions
        Conditions Yield
        With sodium methylate; In methanol; at 20 ℃; for 15h;
        76%
        astragaloside VI
        84687-45-6

        astragaloside VI

        astragaloside IV
        83207-58-3,84687-43-4

        astragaloside IV

        Conditions
        Conditions Yield
        hesperidinase; In water; acetone; at 35 ℃; for 36h;
        35 mg

        83207-58-3 Upstream products

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          cyclosiversioside H

        • 86764-11-6
          86764-11-6

          isoastragalosides II

        • 84676-88-0
          84676-88-0

          isoastragaloside I

        • 84687-46-7
          84687-46-7

          (3β,6α,16β,20R,24S)-20,24-epoxy-16-hydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostane-6,25-diyl bis[β-D-glucopyranoside]

        83207-58-3 Downstream products

        • 84605-18-5
          84605-18-5

          cycloastragenol

        • 86764-12-7
          86764-12-7

          cyclosieversigenin 6-O-β-D-glucopyranoside

        • 86541-79-9
          86541-79-9

          astragenol

        • 86541-83-5
          86541-83-5

          cyclosieversigenin 3-O-β-D-xylopyranoside

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